Clenbuterol
Clenbuterol is a bronchodilator that is used in many parts of the world. This drug is distributed in 20 mcg tablets, a syrup, and injections. This steroid is classified as a sympathomimetics. They affect the sympathetic nervous system in many ways. They are mediated by the distribution of adrenoceptors. The body has nine types of receptors that are classified by alpha or beta. They are subcategorized by type number.
Clenbuterol is frequently used to treat asthma, hypertension, cardiovascular shock, arrhythmias, migraine headaches, and anaphylactic shock. Goodman and Gillman’s The Pharmacological Basis of Therapeutics Edition describes the effect
Clenbuterol has on the body as “Most of the actions of catecholamines and sympathomimetic agents can be classified into seven broad types: (1) peripheral excitatory action on certain types of smooth muscles such as those in blood vessels supplying the skin, kidney, and mucous membranes, and on the gland cells, such as those of the salivary and sweat glands; (2) a peripheral inhibitory action on certain other types of smooth muscle, such as those in the wall of the gut, in the bronchial tree, and in blood vessels supplying skeletal muscle; (3) a cardiac excitatory action, responsible for in increase in heart rate and force of contraction; (4) metabolic actions, such as an increase in the rate of glycogenolysis in liver and muscle and liberation of free fatty acids from adipose tissue; (5) endocrine actions, such as modulation of the secretion of insulin, rennin, and pituitary hormones; (6) CNS actions, such as respiratory stimulation and, with some of the drugs, an increase in wakefulness and psychomotor activity and a reduction in appetite; and (7) presynaptic actions that result in either inhibition or facilitation of the release of the neurotransmitters such as such as norepinephrine and acetylcholine.”
Clenbuterol is a selective beta-2 sympathomimetic, primarily affecting only one of the three subsets of beta-receptors. This drug has very little beta-1 stimulating activity. Since beta-1 receptors are closely tied to the cardiac effects of these agents, this allows Clenbuterol to reduce reversible airway obstruction with less cardiovascular side effects when compared to nonselective beta agonists.
Clinical studies with Clenbuterol show it is extremely effective as a bronchodilator. There are very few user complaints and patients are finding this drug to be very effective. Clenbuterol also exhibits an extremely long life in the body at approximately 34 hours. This makes steady blood levels easy to achieve with only a single dose each day. This makes Clenbuterol a very easy drug to use, and patients seem to use it as directed.
Clenbuterol is used in many countries but it has not been approved for use in the United States. It may have something to do with the number of other asthma medications already in use that are effective. Therefore many drug companies don’t find Clenbuterol profitable enough to undergo the process with the FDA for approval. Many people in the United States purchase Clenbuterol on the black market.
Clenbuterol has been shown to have anabolic activity in animal research, making it a very viable drug for athletes. This compound is additionally a known thermogenic, with beta-2 agonists like Clenbuterol shown to directly stimulate fat cells and accelerate the breakdown of triglycerides to form free fatty acids. This makes Clenbuterol a very attractive drug.
Those who use Clenbuterol are looking for something that will help them lose body fat and increase muscle mass. Medicine and Science in Sports and Exercise published a review in August of 1995 showing that the information is purely based on the results of anabolic activities in animals for bronchodilator. This has lead to ongoing debates about Clenbuterol even being anabolic at all. Many of those who use Clenbuterol claim it has helped them to build muscle mass while some athletes say it was a waste of their money.
There are some possible side effects associated with the use of Clenbuterol including shaking of the hands, insomnia, sweating, higher blood pressure, and nausea. They should subside after using the drug for a week as the body becomes accustomed to the drug in their system. To offset the side effects consider starting with a very small dose of Clenbuterol and slowly increasing the amount each day until you are taking the full dose. Men consume 2 -8 tablets per day and women consume 2-4 tablets daily.
Clenbuterol will cause your body temperature to rise a half degree or so. This is because your body is burning more energy from fat. You won’t feel uncomfortable with the temperature change. This is not a drug for long term use as the effectiveness of it will diminish over time. The length of time it will be effective depends on the individual but it is likely to be from 4-6 weeks. A sign that it is no longer working is that your body temperature returns to normal. Increasing the dose won’t help. You can try to stop using it for a few weeks and then try it again.
Clenbuterol can burn more fat if it is combined with thyroid hormones such as Cytomel. Many athletes have seen amazing results using these two drugs together. They have not had to change their diet either. This mix of drugs is also used for growth hormone therapy that enhance the thermogenic and anabolic effect. Clenbuterol is also often used in ‘cutting’ cycles with anabolic steroids. A common cycle is testosterone, Winstrol, and Clenbuterol.
References 1. Am J Physiol Endocrinol Metab. 2002 Jul;283(1):E146-53 2. Biosci Rep. 1984 Jan;4(1):83-91 3. J Anal Toxicol. 2001 May-Jun;25(4):280-7 4. Med Sci Sports Exerc. 2002 Dec;34(12):1976-85